Scientists Identify Hundreds of New Genetic Risk Factors for Depression in Global Study
A groundbreaking global study has uncovered 300 previously unknown genetic
risk factors for depression by analyzing data from over 5 million people
across 29 countries, including a quarter from non-European ancestries. The
research, led by the University of Edinburgh and King’s College London,
represents a significant step toward understanding depression's genetic
components and addressing health inequalities.
Published in the journal Cell, the study identified 700 variations in DNA linked to depression, nearly half of which were newly associated with the condition. These genetic variations were connected to neurons in brain regions that regulate emotion. Notably, 100 of these differences were discovered due to the inclusion of individuals from African, East Asian, Hispanic, and South Asian backgrounds.
While each genetic factor has a minor impact individually, their cumulative effect can substantially increase the risk of depression. The findings could enhance predictions of depression risk across ethnicities and pave the way for more diverse treatment options.
The study also explored the impact of over 1,600 medications on these genes, identifying potential new treatments, including Pregabalin, used for chronic pain, and Modafinil, used for narcolepsy. Further clinical trials are needed to confirm these drugs' effectiveness for depression.
Researchers emphasized the importance of globally representative studies to better understand depression and develop new therapies. Mental health experts praised the study's diverse sample while highlighting the need to address societal factors like poverty and discrimination, which significantly influence mental health.
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