Scientists Turn to Queen Bees in Search of Secrets to Longevity
For centuries, the mysterious life of queen bees has intrigued scientists. Unlike their worker counterparts, queen bees enjoy extended lives, thriving for years while workers live only a few months, despite having nearly identical genetic material. This unusual longevity has led researchers to investigate whether the key to longer human lives could be found in the biology of these remarkable insects.
This investigation is part of an ambitious new initiative funded by the UK’s Advanced Research + Invention Agency (Aria), a government body backed by £800 million. Aria is focused on supporting high-risk, high-reward projects that may reshape our understanding of aging and fertility efforts that might fail but could also revolutionize human health if successful.
Yannick Wurm, professor of evolutionary genomics and one of Aria’s program directors, sees a potential breakthrough in understanding how nature has solved problems like aging and fertility in animals. "If we can reverse engineer how these creatures achieve their longevity, it could transform human health," he said. The project could have far-reaching applications, from extending human lifespans to improving organ transport and combating diseases.
Aria’s directors are pursuing diverse, nature-inspired solutions, including replacing plastics with sustainable materials, harnessing atmospheric energy for flight, and exploring novel ways to manipulate the immune system to fight diseases. The project on queen bees builds on previous discoveries that have already extended the life of worker bees by transplanting gut microbes from queens.
In their natural environment, queen bees live long lives due to a combination of factors: they mate mid-flight, store sperm from multiple males, and are nurtured with royal jelly, a nutrient-rich secretion. The secrets contained within this royal jelly and the microbes it supports are of particular interest to scientists aiming to unlock the potential for extending human health and fertility.
This project is one of several bold ideas being explored by Aria, a research body modeled after the influential U.S. Defense Advanced Research Projects Agency (DARPA), which is known for its groundbreaking technological innovations.
Despite the potential, Aria acknowledges the high level of uncertainty inherent in such speculative research. “We often describe our programmes as sending up a flare,” says Pippy James, Aria’s chief product officer. “It’s about showing that something is possible, even if it takes time to bear fruit.”